Reply to Zhao et al .: Clarifying Structural – Functional Coupling by FeNO Status in VESTIGE

Key Points

• This research aims to clarify the relationship between structural and functional coupling based on FeNO status.
• Discussed findings and interpretations from Zhao et al.
• Analyzed implications of FeNO as a biomarker in functional assessments
• Provided insights on the VESTIGE cohort's structural-functional dynamics
• Clarified misconceptions regarding the interpretation of FeNO status in structural-functional coupling.
• Highlighted the relevance of FeNO as a significant biomarker in assessing lung function.