DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction

In mammals, the resetting of DNA methylation patterns in early embryos and germ cells is crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns. Dnmt3L, a member of the Dnmt3 family, has been reported to be necessary for maternal methylation imprinting, possibly by interacting with Dnmt3a and/or Dnmt3b (Hata, K., Okano, M., Lei, H., and Li, E. (2002) Development 129, 1983-1993). In the present study, the effect of DNMT3L, a human homologue of Dnmt3L, the DNA methylation of Dnmt3a and Dnmt3b in the DNA methylation of Dnmt3a and Dnmt3b in a the DNA methylation of the of a effect the DNA methylation for of the DNA of the and the the of the the and to DNA to Dnmt3a and Dnmt3b, the effect of the DNA methylation be to the of Dnmt3a and Dnmt3b to the DNA a effect of to be responsible for the of the In mammals, the resetting of DNA methylation patterns in early embryos and germ cells is crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns. Dnmt3L, a member of the Dnmt3 family, has been reported to be necessary for maternal methylation imprinting, possibly by interacting with Dnmt3a and/or Dnmt3b (Hata, K., Okano, M., Lei, H., and Li, E. (2002) Development 129, 1983-1993). In the present study, the effect of DNMT3L, a human homologue of Dnmt3L, the DNA methylation of Dnmt3a and Dnmt3b in the DNA methylation of Dnmt3a and Dnmt3b in a the DNA methylation of the of a effect the DNA methylation for of the DNA of the and the the of the the and to DNA to Dnmt3a and Dnmt3b, the effect of the DNA methylation be to the of Dnmt3a and Dnmt3b to the DNA a effect of to be responsible for the of the In of in in DNA is DNA and DNA methylation of the is for and crucial in a of of and of In of DNA been and DNA is in the and methylation in and germ cells and is to be in the of DNA methylation Dnmt3L, DNA of of Dnmt3L, DNA of of in the of the the methylation patterns been are in a to the of the DNA methyltransferases, is responsible for of the DNA methylation patterns the Dnmt3a and Dnmt3b are for DNA methylation in embryos E. E. 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