Diabetes mellitus was strongly associated with the presence of cardiovascular disease in patients with breast cancer (OR 4.472), lung cancer, colorectal cancer, and gastric cancer.
Cross-Sectional (n=35,861)
No
Cancer patients have a significant burden of cardiovascular disease, with hypertension being the most common and diabetes mellitus strongly associated with cardiovascular disease across most cancer types.
Effect estimate: OR 4.472 (95% CI 3.075-6.504)
p-value: p=<0.001
Introduction: Understanding the epidemiology of cardiovascular disease (CVD) related comorbidity is a key strategy for improving the outcomes of patients with cancer. Therefore, this study aimed to assess the distribution of cardiovascular comorbidities and cardiovascular risk factors (CVRF) among five cancer sites. Methods: This is a single-centered, cross-sectional study performed in Dalian, China. Between 2008 and 2018, all newly diagnosed cancer in the First Affiliated Hospital of Dalian Medical University, China were screened. Clinical data were extracted from a comprehensive electronic health record system. Results: 35861 patients with lung, colorectal, gastric, breast, and thyroid cancer were collected retrospectively. The most prevalent CVDs in descending order were hypertension (21.9%), followed by coronary heart disease (6.5%), atrial fibrillation (2.9%), and heart failure (1%). The prevalence of hypertension significantly varies between lung (21.3%), colorectal (27.3%), gastric (22.5%), breast (16.7%), and thyroid cancer (22.4%) ( P 0.001). CVRF varies with cancer sites. Age, sex, total cholesterol, triglyceride, low-density lipoprotein cholesterol, systolic blood pressure, smoking, alcohol use, and diabetes mellitus (DM) are common risk factors associated with CVD at different cancer sites. The association between DM and presence of CVD was strong in breast (odds ratio OR = 4.472, 95% confidence interval CI: 3.075–6.504, P 0.001), lung (OR = 3.943; 95% CI: 3.270–4.754, P 0.001), colorectal (OR = 3.049; 95% CI: 2.326–3.996, P 0.001), and gastric (OR = 2.508; 95% CI: 1.927–3.264, P 0.001) cancer. Conclusion: Cancer patients had a significant burden of CVD and increased CVRF. The prevalence of CVRF and CVD comorbidity differ for cancer types. DM remains significantly associated with CVD at different cancer sites except for thyroid cancer.
Li et al. (Tue,) conducted a cross-sectional in Adult-onset cancers (lung, colorectal, gastric, breast, thyroid) (n=35,861). Diabetes mellitus vs. No diabetes mellitus was evaluated on Presence of cardiovascular disease in breast cancer patients (OR 4.472, 95% CI 3.075-6.504, p=<0.001). Diabetes mellitus was strongly associated with the presence of cardiovascular disease in patients with breast cancer (OR 4.472), lung cancer, colorectal cancer, and gastric cancer.