Atrial fibrillation was more strongly associated with HFpEF (HR 2.02; 95% CI 1.80-2.26), while cardiomyopathy was more strongly associated with HFrEF (HR 4.37; 95% CI 3.21-5.97) in older adults.
Cohort
Different risk factors drive the development of HFpEF versus HFrEF in the elderly, with atrial fibrillation strongly predicting HFpEF and prior myocardial infarction or cardiomyopathy predicting HFrEF.
BACKGROUND: The differential impact of various demographic characteristics and comorbid conditions on development of heart failure (HF) with preserved (pEF) and reduced ejection fraction (rEF) is not well studied among the elderly. METHODS: Using Medicare claims data linked to electronic health records, we conducted an observational cohort study of individuals ≥65 years of age without HF. A Cox proportional hazards model accounting for competing risk of HFrEF and HFpEF incidence was constructed. A gradient-boosted model (GBM) assessed the relative influence (RI) of each predictor in the development of HFrEF and HFpEF. RESULTS: for heterogeneity 35%. Atrial fibrillation was the most influential comorbidity for the development of HFpEF (RI = 8.4%) while cardiomyopathy was the most influential comorbidity for the development of HFrEF (RI = 20.7%). CONCLUSION: These findings of heterogeneous relationships between several important risk factors and heart failure types underline the potential differences in the etiology of HFpEF and HFrEF.
Lee et al. (Mon,) conducted a cohort in Heart failure. Risk factors (demographics and comorbidities) was evaluated on Incidence of HFrEF and HFpEF. Atrial fibrillation was more strongly associated with HFpEF (HR 2.02; 95% CI 1.80-2.26), while cardiomyopathy was more strongly associated with HFrEF (HR 4.37; 95% CI 3.21-5.97) in older adults.