Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries

We describe a general method for the selection of compounds from self-assembled libraries which employs an immobilized receptor (i.e., and affinity reagent) to effect the selection. Using commercially available oligo d(A·T) DNA-cellulose resin, a set of three setereoisomeric coordination complexes are identified as DNA binding compounds from an equilibrating, self-assembled library of 36 bis(salicyladiminato)-zinc coordination complexes.