Does pharmacogenomic-guided warfarin treatment improve cost-effectiveness and clinical outcomes in elderly Croatian atrial fibrillation patients with ischemic stroke?
Pharmacogenomic-guided warfarin treatment may be a cost-effective strategy for managing elderly patients with atrial fibrillation and ischemic stroke in Croatia.
BACKGROUND 95% CI: 84.00-93.87%, p < 0.05). The total cost per patient was estimated at €538.7 (95% CI: €526.3-551.2) for the PGx-guided group versus €219.7 (95% CI: €137.9-304.2) for the control group. In terms of quality-adjusted life-years (QALYs) gained, total QALYs was estimated at 0.954 (95% CI: 0.943-0.964) and 0.944 (95% CI: 0.931-0.956) for the PGx-guided and the control groups, respectively. The true difference in QALYs was estimated at 0.01 (95% CI: 0.005-0.015) in favor of the PGx-guided group. The incremental cost-effectiveness ratio of the PGx-guided versus the control groups was estimated at €31,225/QALY. CONCLUSION: Overall, our data indicate that PGx-guided warfarin treatment may represent a cost-effective therapy option for the management of elderly patients with atrial fibrillation who developed ischemic stroke in Croatia.
Mitropoulou et al. (Thu,) studied this question.