Alkaline Phosphatase

Review1 July 1967Alkaline PhosphataseSOLOMON POSEN, M.D., F.R.A.C.P.SOLOMON POSEN, M.D., F.R.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-183 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term alkaline phosphatase (International Enzyme Classification 3:1:3:1 (I)) is applied to a group of enzymes sharing the capacity to hydrolyze phosphate esters in an alkaline medium. Since the first* description of a phosphatase by Suzuki, Yoshimura, and Takaishi (2) in 1907 the subject has been repeatedly reviewed (4-16), and this article surveys some of the progress in our knowledge of this group of enzymes made since the appearance of Gutman's (15) comprehensive paper. Particular emphasis will be placed on those advances with a direct bearing on clinical medicine.STRUCTUREIn spite of many attempts to prove the existence of...References1. DIXONWEBB MEC: Enzymes, 2nd ed. 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