Does circulating LIPCAR level predict the diagnosis of heart failure in patients post-acute myocardial infarction?
Circulating LIPCAR levels are significantly elevated in patients who develop heart failure after an acute myocardial infarction, demonstrating high diagnostic accuracy (AUC 0.985) as a potential early biomarker.
In heart failure (HF) patients with reduced ejection fraction, LIPCAR, a long noncoding RNA is elevated and is associated with left ventricular remodeling and poor prognosis. We studied the role of LIPCAR in patients with HF post-acute myocardial infarction (AMI) to find biomarkers for early detection of HF. We conducted a study of 127 patients with AMI, of which 59 were patients with HF post-AMI. LIPCAR levels were higher in HF patients post-AMI than patients without HF, and LIPCAR had a high predictive value for diagnosis of HF, which was estimated by receiver operating characteristic curves (AUC: 0.985). The results indicate that LIPCAR may be a marker of early HF after AMI.
Li et al. (Mon,) studied this question.