What question did this study set out to answer?

To explore the occurrence of high-grade penile intraepithelial neoplasia in a patient undergoing treatment with tofacitinib.

June 1, 2026

A case of penile intraepithelial neoplasia during treatment with Tofacitinib

Key Points

To explore the occurrence of high-grade penile intraepithelial neoplasia in a patient undergoing treatment with tofacitinib.
Patient presentation of penile intraepithelial neoplasia five months after tofacitinib initiation.
Histopathology confirmed diagnosis with p16 and Ki-67 positivity.
Treatment involved discontinuation of tofacitinib and interventions with cryotherapy and topical imiquimod.
Histopathological analysis confirmed high-grade penile intraepithelial neoplasia post tofacitinib treatment.
Lesions showed improvement after stopping tofacitinib and receiving cryotherapy and imiquimod treatment.

Abstract

A 41-year-old man with PASH syndrome developed high-grade penile intraepithelial neoplasia five months after initiating tofacitinib for refractory disease. Histopathology confirmed PeIN with diffuse p16 and Ki-67 positivity, and the lesions improved after discontinuation of tofacitinib and treatment with cryotherapy and topical imiquimod. This case highlights a potential association between JAK inhibition and HPV-related neoplasia, underscoring the importance of vigilance for mucocutaneous HPV lesions during treatment.

اسأل الذكاء الاصطناعي

Bookmark

Cite This Study

Balado‐Simó et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1d221f02fbce9130637e84 https://doi.org/https://doi.org/10.1093/ced/llag230

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

اسأل الذكاء الاصطناعي

Bookmark