This update highlights foundational physiological findings demonstrating that nocturnal blood pressure reduction is primarily driven by decreased total peripheral resistance and altered baroreflex sensitivity during sleep.
sleep in normal and hypertensive subjects; the significant reduction of total peripheral resistance as a major deter- In 1969, Bristow, Honour, Pickering and Sleight 1 minant of nocturnal arterial pressure reduction in the provided us with one of the very first descriptions of the absence of significant changes in cardiac output; the cardiovascular and respiratory changes occurring during identification of changes in baroreflex sensitivity as well as sleep in normal and hypertensive subjects. The study was a resetting of the arterial baroreflex during sleep in carried out in 19 subjects, eight with normal and ten with hypertensives. high blood pressure, while one subject was suffering from
Federico Lombardi (Sat,) studied this question.
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