Electroconvulsive therapy (ECT) successfully reduced the frequency and severity of self-injurious and violent behavior in an adolescent with a CACNA1D mutation and excited catatonia.
Case Report (n=1)
No
Does electroconvulsive therapy reduce self-injurious and violent behavior in an adolescent with a CACNA1D mutation and excited catatonia?
Electroconvulsive therapy can be safely and effectively used to treat excited catatonia in patients with CACNA1D mutations.
Autism spectrum disorder (ASD) may be a predisposing factor in the development of catatonia, which has been demonstrated to be effectively treated using electroconvulsive therapy (ECT). CACNA1 channelopathy mutations have been associated with autism spectrum disorder, intellectual disability, and epilepsy. The single published case report of ECT use in CACNA1 subunit mutations demonstrated a negative outcome, and no current case reports on CACNA1B, CACNA1C, CACNA1D, or CACNA1E mutations have been published. We present a case of an adolescent with a known CACNA1D mutation and symptoms of excited catatonia who experienced a reduction in the frequency and severity of self-injurious and violent behavior following treatment with ECT. Our case demonstrates the use of ECT for catatonia in an individual with a CACNA1 mutation without complication and with a positive therapeutic response.
Mancine et al. (Tue,) conducted a case report in CACNA1D-Associated Catatonia and Severe Autism Spectrum Disorder (n=1). Electroconvulsive therapy (ECT) was evaluated on Frequency and severity of self-injurious and violent behavior. Electroconvulsive therapy (ECT) successfully reduced the frequency and severity of self-injurious and violent behavior in an adolescent with a CACNA1D mutation and excited catatonia.