A submaximal exercise bout in male patients with coronary artery disease significantly reduced nitroglycerin-mediated dilation during early recovery compared to rest (14.4% vs 22.0%, P<0.001).
Observational (n=19)
Does a submaximal exercise bout alter brachial artery endothelial responses in male patients with coronary artery disease?
Submaximal exercise in CAD patients attenuates endothelial-independent vasodilation during early recovery, highlighting the need for comprehensive endothelial assessment in exercise interventions.
Absolute Event Rate: 14.4% vs 22%
p-value: p=<0.001
This study examined the acute endothelial responses to an exercise bout in coronary artery disease (CAD) patients. Nineteen males with CAD (63 ± 8 years) were assessed at rest and 15 minutes following a submaximal exercise bout (recovery). Brachial artery endothelial-dependent function was assessed using flow-mediated dilation (FMD). Brachial artery diameters and velocities were measured using Duplex ultrasound at baseline, and for 3 minutes following a 5-minute ischemic period. Endothelial-independent function was assessed using a 0.4 mg dose of nitroglycerin (NTG). FMD responses were unchanged from rest to recovery; however, there were 2 types of responses: negative and positive FMD responders. Post-hoc analysis revealed that positive responders had lower resting FMD compared to negative responders (3.2 ± 1.7 versus 6.0 ± 2.5%, P < 0.05). NTG-mediated dilation was reduced in recovery (22.0 ± 5.6 versus 14.4 ± 5.7%, P < 0.001 for rest versus recovery). In conclusion, acute endothelial-dependent responses to submaximal exercise are affected by the degree of resting endothelial dysfunction. The observation of attenuated NTG-mediated dilation during recovery is novel and warrants the investigation of possible mechanisms and clinical significance. Furthermore, it highlights the necessity of both endothelial-dependent and endothelial-independent assessments when evaluating endothelial function changes with an intervention.
Currie et al. (Wed,) conducted a observational in Coronary Artery Disease (n=19). Submaximal exercise bout vs. Rest (baseline) was evaluated on Nitroglycerin (NTG)-mediated dilation (p=<0.001). A submaximal exercise bout in male patients with coronary artery disease significantly reduced nitroglycerin-mediated dilation during early recovery compared to rest (14.4% vs 22.0%, P<0.001).