A 2-week intervention with Kuan-Sin-Yin improved autonomic dysfunction in metastatic colon cancer patients by increasing vagal tone (P=0.041) and total autonomic activity (P=0.013).
Does Kuan-Sin-Yin improve autonomic function in metastatic colon cancer patients with autonomic dysfunction?
A 2-week intervention with Kuan-Sin-Yin decoction improved autonomic function, cancer-related symptoms, and quality of life in patients with metastatic colon cancer.
p-value: P = .013
BACKGROUND: Kuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on cancer cells and involved in the TCM theory of promoting yin-yang balance.Sonce many cancer patients suffer from autonomic dysfunction (AD), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic colon cancer (mCRC) patients with AD. METHODS: We conducted a single-group experiment. Total 52 qualified patients were enrolled. Participants took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were cancer-related symptoms and patient quality of life (QoL). RESULTS: The results showed that the KSY intervention improved AD via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). Cancer-related symptoms and QoL were significantly improved (P < .05). CONCLUSION: The safety and effectiveness of KSY in improving AD in mCRC patients are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.
Chien et al. (Wed,) conducted a other in Metastatic colon cancer with autonomic dysfunction (n=52). Kuan-Sin-Yin (KSY) was evaluated on Heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points (p=P = .013). A 2-week intervention with Kuan-Sin-Yin improved autonomic dysfunction in metastatic colon cancer patients by increasing vagal tone (P=0.041) and total autonomic activity (P=0.013).