Male sex was associated with significantly higher 24-hour systolic blood pressure compared to female sex (135.5 vs 131.6 mmHg; p<0.001), alongside significant age-related blood pressure variations.
Observational (n=65,894)
Yes
In a large Hungarian registry, ambulatory blood pressure monitoring revealed significant sex and age differences, with men having higher 24-hour systolic and diastolic blood pressures than women.
Absolute Event Rate: 135.5% vs 131.6%
p-value: p=<0.001
Objective: The ambulatory blood pressure monitoring (ABPM) registry initiated by the Hungarian Society of Hypertension has been collecting data since 2021. The objective of this sub-study was to assess the results by sex and age distribution. Design and method: Between 2021 and 2025, ABPM data from a total of 65,894 patients (mean age: 56±15.1 years) were recorded. 45.4% were men and 54.6% were women. All analyses were performed in Python using pandas, numpy and statsmodels libraries. Results: The 24-hour systolic blood pressure (SBP) was significantly higher in men compared with women (135.5±13.3 mmHg vs 131.6±14.6 mmHg; p< 0.001). The 24-hour diastolic blood pressure (DBP) showed similar difference (81.1±10 mmHg vs 77.1±9.9 mmHg; p < 0.001). There wasn’t any clinically significant difference in the heart rate (HR) 72.5±9.9 /min in men and 72.9±9.2 /min in women. Both daytime and nighttime BP values were significantly higher in men compared with women, without any differences in HR. Analyzing the differences in BP between the two sexes on an hourly basis, we observed a continuous difference, which proved to be most significant between 10 pm to 4 am, while women experienced a greater ‘morning surge’ in BP between 4 am to 8 am. While we observed only 1-2 mmHg differences in the mean 24-hour SBP values across age groups, the 24-hour DBP was highest in the 35–49-year age group (84.3±9.3 mmHg) and was significantly lower in the older age groups (50–64, 65–79, and 80–99 years: 81±9.1, 73.5±8.5, 68.5±8.3 mmHg; p<0.001). The 24-hour HR decreased significantly with advancing age. Similar age-related differences were observed for daytime and nighttime mean BP and HR values. Upon closer analysis of SBP, we observed significantly lower BP in older individuals between 10 am and 4 pm. Conclusions: Based on ABPM results from a large Hungarian population, this study confirms a significant impact of sex and age on most of the examined parameters. These findings underscore the clinical utility of ABPM and highlight the importance of considering sex and age in the routine management of hypertension.
Lengyel et al. (Fri,) conducted a observational in Hypertension (n=65,894). Male sex vs. Female sex was evaluated on 24-hour systolic blood pressure (p=<0.001). Male sex was associated with significantly higher 24-hour systolic blood pressure compared to female sex (135.5 vs 131.6 mmHg; p<0.001), alongside significant age-related blood pressure variations.