Abstract Colour vision changes are a key clinical feature of many acquired retinal and optic nerve disorders. Current clinical tests are often labour-intensive or designed for congenital defects. We introduce the novel LSS-8 test, which measures colour saturation thresholds across eight hues. Three cohorts with mixed ocular health underwent testing in a diagnostic crossover study. The reliability cohort was tested with LSS-4 on different days ( n = 30 eyes). The screen independence cohort used LSS-8 with 11-inch versus 13-inch screens in random order ( n = 27 eyes). Brightness independence testing used LSS-8 at 115 cd/m 2 versus 230 cd/m 2 ( n = 19 eyes). Scores for each plate set and total scores were recorded. Intraclass correlation coefficients (ICC) and absolute difference frequency distributions were calculated. Data from 74 eyes (74 subjects; mean age 62.4 ± 19.1 years; range 20–85; 39% female) were analysed. LSS-4 test-retest reliability with ICC(2,1) was excellent (mauve 0.93, red 0.95, green 0.87, blue 0.91, total score 0.96). LSS-8 screen independence testing showed excellent reliability for mauve, green, pink and total scores (ICC(2,k) 0.74–0.98), and moderate to good reliability for other hues. Varying screen brightness did not produce significant score differences in most participants. The LSS is a simple, reliable test with potential for rapid quantification of acquired colour vision defects.
Stepnicka et al. (Sat,) studied this question.