Stress Granules and Tau Pathology in Alzheimer’s Disease: A Scoping Review of Bidirectional Interactions, Liquid-Liquid Phase Separation, and Proteostatic Consequences

Key Points

• This review aims to explore the complex interactions between stress granules and tau pathology in Alzheimer’s Disease (AD).
• Conducted a scoping review of literature on stress granules and tau pathology in AD.
• Analyzed bidirectional interactions, liquid-liquid phase separation, and proteostatic consequences.
• Evaluated potential therapeutic strategies involving SG modulation and autophagy enhancers.
• Stress granules are linked to tau pathology and RNA dysregulation in AD.
• Modulating stress granules may present a novel treatment approach for AD.
• Autophagy enhancers, such as mTOR inhibitors and myricetin, show potential in diminishing tau pathology.