Sinonasal and Pulmonary Computed Tomography Images Before and After Triple-Combination Therapy in a Patient with Cystic Fibrosis Without ΔF508 Mutations

Key Points

• To assess the effects of triple-combination therapy on sinonasal and pulmonary conditions in a patient with unique cystic fibrosis mutations.
• Patient with G542X and G85E cystic fibrosis mutations underwent computed tomography examinations before and after treatment.
• Focus on sinonasal and lung involvement improvement post-triple-combination therapy initiation.
• Case documented over a 2-year period following treatment.
• Clear improvement in sinonasal and lung involvement observed in CT images after treatment.
• First report demonstrating sinonasal improvement in a patient with G542X/G85E mutations post-combination therapy.