In civilian hypertensive patients in Ukraine, mental health disorders (prevalence 45.2%) were associated with higher systolic BP (+11%), heart rate (+11.8%), and abnormal diurnal BP patterns (60.1%).
Cross-Sectional (n=208)
Are mental health disorders and sleep disturbances associated with adverse cardiovascular risk factors in civilian hypertensive patients living under armed conflict?
In civilian hypertensive patients living under armed conflict in Ukraine, mental health disorders and sleep disturbances are highly prevalent and associated with worse blood pressure control and higher cardiovascular risk.
Objective: To evaluate the relationship between mental health disorders (MHD), sleep quality, and cardiovascular (CV) risk factors in civilian essential hypertensive (EH) patients (pts) in the context of armed conflict in Ukraine. Design and method: We studied 208 treated EH pts without previously diagnosed MHD. The clinical characteristics and laboratory parameters were assessed. Anxiety/depression were evaluated using the HADS, GAD-7, and PHQ-9 scales, whole sleep quality was assessed using the PSQI. Results: The prevalence of MHD was 45.2%. There were no significant differences between patients without MHD (group 1) and those with MHD (group 2) in terms of age, sex, duration of hypertension, family history of premature CVD, or body mass index. A significantly higher prevalence of smoking, alcohol consumption, diabetes mellitus (DM), and prior stroke/TIA, as well as a higher waist-to-height ratio, was observed in group 2. Patients with MHD had significantly higher office systolic BP (SBP) (+11%), mean 24-hour SBP (+10.2%), and heart rate (HR) (+11.8%). Abnormal diurnal BP patterns were more frequently detected in group 2 (60.1%), predominantly of the non-dipper type (37.5%), and were associated with increased daytime and nighttime SBP variability. Masked uncontrolled hypertension was identified in 16.3% of patients with MHD. Significant correlations were found between the severity of MHD symptoms and diurnal SBP index (r = - 0.350, P = 0.048), HR (r = 0.341, P = 0.046), active smoking status (r = 0.306, P = 0.040), and eGFR (r = - 0.339, P = 0.040). Sleep quality was correlated with eGFR (r = - 0.382, P = 0.040), variability of nighttime SBP (r = 0.337, P = 0.031), and diastolic BP (r = 0.321, P = 0.048). Conclusions: Civilian EH pts living in Ukraine under conditions of armed conflict demonstrate a high prevalence of MHD and sleep disturbances. These conditions are associated with adverse health behaviors, DM, cerebrovascular complications, higher BP levels, abnormalities of the circadian BP profile, and the presence of masked hypertension.
Матова et al. (Fri,) conducted a cross-sectional in Essential hypertension (n=208). Mental health disorders (MHD) vs. Patients without MHD was evaluated on Cardiovascular risk factors, blood pressure parameters, and sleep quality. In civilian hypertensive patients in Ukraine, mental health disorders (prevalence 45.2%) were associated with higher systolic BP (+11%), heart rate (+11.8%), and abnormal diurnal BP patterns (60.1%).