Body mass index was a statistically significant positive predictor of 24-hour augmentation index in patients with stage 1 primary hypertension (beta=0.512, p<0.01).
Observational (n=154)
In patients with stage 1 primary hypertension, higher body mass index is directly correlated with increased arterial stiffness as measured by 24-hour augmentation index.
Effect estimate: beta = 0.512
p-value: p=< 0.01
Objective: Obesity and even overweighted patients are directly related to an increased incidence of cardiovascular diseases. There are various pathophysiological mechanisms through which excessive bogy weight leads to increased arterial stiffness (AT) and include: hyperinsulinemia and excessive activation of the RAAS system, excessive activation of the sympathetic nervous system (SNS. The aim of this research is to determine the relationship between the body mass index and the parameters of arterial stiffness in the population of patients at the begging of cardiovascular continuum. Design and method: This study included 154 patients with stage 1 primary hypertension (69.5% female, mean age 38.5 years). Arterial stiffness parameters were measured using the office method of implanted tonometry (SphygmoCor) and 24-hour monitoring using Mobil-o-Graph and Arteriograph, but pulse wave velocity calculated using a validated equation (ePWV) was also assessed. Results: In the studied cohort, the average age of the subjects was 38.75±12.65, with an average BMI of 28.51±4.22. The largest number of respondents (48.7%) is in the overweight category, while 31.2% of respondents were obese according to BMI. Multiple regression analyzes in which the augmentation index (AiX) was measured on an outpatient basis and determined as categorical variables during 24 hours indicated the importance of BMI. In the case when AiX was measured during 24 h using the Arteriograph set as a categorical variable, the only statistically significant predictor was the body mass index - BMI, which was positively correlated with the criterion variable (beta= 0.512, p < 0.01). In the case where AiX measured during 24 h using Mobil-O-Graph was set as a categorical variable, the regression model proved to be statistically significant (F = 3.465, p < 0.01), and the explained variance was 39.4%. The only statistically significant predictor was BMI (beta = 0.425, p < 0.05) in this case. Conclusions: The results of our study showed a direct correlation between body mass index and augumentation index measured during 24 hours (Mobil-O-Graph and Arteriograph) in the examined cohort of patients at the begging of cardiovascular risk with low CV risk.
Prelević et al. (Fri,) conducted a observational in Stage 1 primary hypertension (n=154). Body mass index (BMI) was evaluated on Augmentation index (AiX) measured during 24 hours (beta = 0.512, p=< 0.01). Body mass index was a statistically significant positive predictor of 24-hour augmentation index in patients with stage 1 primary hypertension (beta=0.512, p<0.01).