Objective: Previous studies have confirmed a significant correlation between lactate dehydrogenase (LDH) levels and cardiac and cerebrovascular disease (CVD) prognosis in acute events. However, further validation of the association between LDH and CVD is needed for the general hypertensive patient population. Design and method: A cross-sectional design was employed to evaluate the relationship between LDH and CVD. In this study, LDH was analyzed as both a continuous variable and a categorical variable. Multivariate logistic regression models were constructed to explore the association between LDH and CVD. To ensure the findings were robust, subgroup analyses were also conducted. Results: Of the 25,735 clinical patients, the mean age was 50.85 ± 12.63 years, 56.49% were male and 1,416 had CVD. For every 20-unit increase in LDH, the odds ratio (OR) increased by 1.05-fold in all participants, by 1.04-fold in male participants, and by 1.07-fold in female participants. When LDH was grouped according to the three tertiles, the Q3 tertile demonstrated significantly elevated CVD risk compared to the Q1 tertile, with corresponding odds ratios (ORs) of 1.25 (95% CI, 1.08–1.45), 1.21 (95% CI, 1.01–1.45), and 1.32 (95% CI, 1.02–1.71) in the total cohort, respectively. Conclusions: In hypertensive patients, elevated LDH levels are independently linked to an increased risk of CVD.
Wang et al. (Fri,) studied this question.