Cumulative systolic blood pressure was independently associated with study-defined incident chronic kidney disease (HR 1.45; 95% CI 1.15-1.83).
Cohort (n=2,821)
Is long-term blood pressure burden and variability associated with kidney function decline in adults with preserved kidney function?
Long-term cumulative systolic blood pressure burden is independently associated with accelerated kidney function decline and incident CKD in adults with preserved baseline kidney function.
Hazard Ratio: 1.45 (95% CI 1.15–1.83)
ABSTRACT Long‐term blood pressure (BP) burden and visit‐to‐visit BP variability may better capture cumulative hemodynamic stress on the kidneys than single‐visit BP measurements, yet evidence linking these metrics with kidney function decline in the general population remains limited. We analyzed 2,821 adults with preserved kidney function from a prospective cohort study. Cumulative BP exposure and visit‐to‐visit BP variability were derived from BP measurements obtained at baseline and two follow‐up visits. Outcomes included annual estimated glomerular filtration rate (eGFR) slope and study‐defined incident chronic kidney disease (CKD). Higher long‐term BP exposure, particularly systolic BP (SBP), and greater BP variability were associated with faster kidney function decline. A 1‐standard deviation increase in cumulative SBP was associated with a more negative annual eGFR slope (β≈−0.15 to −0.18 mL/min/1.73 m 2 per year). Cumulative SBP was also independently associated with study‐defined incident CKD (hazard ratio 1.45; 95% confidence interval 1.15–1.83), whereas associations for diastolic BP and BP variability were generally weaker. No evidence of nonlinearity or significant effect modification was observed. These findings suggest that long‐term BP burden, particularly cumulative SBP, is associated with accelerated kidney function decline in the general population.
Xie et al. (Mon,) conducted a cohort in Kidney function decline (n=2,821). Long-term blood pressure burden and variability (cumulative SBP) was evaluated on Annual estimated glomerular filtration rate (eGFR) slope and study-defined incident chronic kidney disease (CKD) (HR 1.45, 95% CI 1.15-1.83). Cumulative systolic blood pressure was independently associated with study-defined incident chronic kidney disease (HR 1.45; 95% CI 1.15-1.83).