24-hour systolic central blood pressure was significantly associated with silent brain infarcts (B=1.335; 95% CI 1.030-1.730; P=0.029) independently of 24-hour peripheral blood pressure.
Cross-Sectional (n=47)
No
Is central blood pressure better associated with silent brain infarcts than peripheral blood pressure in hypertensive patients?
24-hour systolic central blood pressure is independently associated with silent brain infarcts in hypertensive patients, suggesting it may be a superior marker for end-organ damage compared to peripheral blood pressure.
Effect estimate: B 1.335 (95% CI 1.030-1.730)
p-value: p=0.029
Objective: Central hemodynamic indices have been shown to be independently associated with end-organ damage and cardiovascular disease. Moreover, central blood pressure (CBP) was shown to be slightly but consistently superior to peripheral blood pressure (PBP) in predicting end-organ damage such as left ventricular hypertrophy and common carotid artery intima-media thickness. Aim of our study was to evaluate whether CBP is better associated with silent brain infarcts than PBP in hypertensive patients. Design and method: A total of 47 hypertensive patients without history of diabetes mellitus and stoke or neurological disease were referred for evaluation at the Hypertension Unit of our department. The patients underwent office blood pressure measurements and 24-h ambulatory blood pressure monitoring of CBP and PBP values. The presence of silent infarcts was assessed by brain MRI. Independent T-test and logistic regression analyses were used to evaluate the association between blood pressure parameters and silent brain infarcts. Results: The mean age of the study population was 68 years. The mean office, 24-h PBP and 24-h CBP were 149/84mmHg, 138/85mmHg, 141/87mmHg, respectively. The brain MRI revealed 6 patients with silent infarcts. The logistic regression analysis demonstrated that 24-h systolic CBP was significantly and positively associated with the presence of silent infarcts (B=1.335 95%CI 1.030 – 1.730, p=0.029) after adjusting for age, sex, smoking, hyperlipidemia, body mass index and 24-h systolic PBP. Conclusions: 24-h systolic CBP was significantly associated with silent brain infarcts presence independently of demographic characteristics, risk factors and 24-h PBP in hypertensive patients
Spiliopoulou et al. (Fri,) conducted a cross-sectional in Hypertension (n=47). 24-h systolic central blood pressure (CBP) vs. 24-h systolic peripheral blood pressure (PBP) was evaluated on Presence of silent brain infarcts assessed by brain MRI (B 1.335, 95% CI 1.030-1.730, p=0.029). 24-hour systolic central blood pressure was significantly associated with silent brain infarcts (B=1.335; 95% CI 1.030-1.730; P=0.029) independently of 24-hour peripheral blood pressure.