A multi-province acute gastroenteritis outbreak in Argentina was linked to a potential novel lineage of GII.17[P17] norovirus with amino acid substitutions in the major viral capsid protein.
Observational
Yes
First report of a potential new lineage of norovirus GII.17[P17] in the Southern Hemisphere, highlighting the need for active genomic surveillance.
Noroviruses represent one of the leading causes of outbreaks and sporadic acute gastroenteritis (AGE) cases across all age groups. Although the GII.4 norovirus has been identified as the primary cause of most AGE outbreaks, the transient predominance of other genotypes has been reported globally. In this study, we describe a multi-province AGE outbreak caused by a potential new lineage of norovirus GII.17P17, which has been recently detected at a high incidence in the United States and Europe. An amino acid analysis of the major viral capsid protein revealed several substitutions in the hypervariable region compared to strains circulating in the mid-2010s, which could play a key role in immune evasion. This is the first report of the detection of these viruses in the Southern Hemisphere, underscoring the importance of maintaining active genomic surveillance in the context of increasing numbers of acute gastroenteritis outbreaks.
Gomes et al. (Wed,) conducted a observational in Acute gastroenteritis. Potential novel lineage of GII.17[P17] norovirus was evaluated on Amino acid substitutions in the hypervariable region of the major viral capsid protein. A multi-province acute gastroenteritis outbreak in Argentina was linked to a potential novel lineage of GII.17[P17] norovirus with amino acid substitutions in the major viral capsid protein.