Plasticizer-responsive molecular axes in heart failure: a subtype-aware toxicogenomic framework relevant to environmental health

Key Points

• This research aims to explore how plasticizers affect different subtypes of heart failure using a toxicogenomic approach.
• Examined molecular responses to plasticizer exposure in heart failure samples.
• Employed a toxicogenomic framework to analyze gene expression related to plasticizers.
• Focused on various subtypes of heart failure to understand differential responses.
• Identified specific molecular pathways disrupted by plasticizers in heart failure subtypes.
• Found notable variations in gene expression linked to environmental exposure, suggesting subtype-specific effects.
• Reported significant insights into the role of environmental health in heart failure mechanisms.