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Models based on system calls are a popular and common approach to characterize the run-time behavior of programs. For example, system calls are used by intrusion detection systems to detect software exploits. As another example, policies based on system calls are used to sandbox applications or to enforce access control. Given that malware represents a significant security threat for today's computing infrastructure, it is not surprising that system calls were also proposed to distinguish between benign processes and malicious code.
Lanzi et al. (Mon,) studied this question.