The automatic tracking algorithm for atrioventricular plane displacement in CMR images showed good agreement with manual measurements, with a mean bias of -0.6 mm in the left ventricle and -0.8 mm in the right ventricle.
Observational (n=153)
Yes
Does an automatic tracking algorithm accurately measure atrioventricular plane displacement in CMR images compared to manual measurements in healthy subjects, athletes, and post-MI patients?
The proposed automatic tracking algorithm accurately measures atrioventricular plane displacement in CMR images with low bias and good agreement compared to manual measurements.
Mean Difference: -0.6
BACKGROUND: Atrioventricular plane displacement (AVPD) is an indicator for systolic and diastolic function and accounts for 60% of the left ventricular, and 80% of the right ventricular stroke volume. AVPD is commonly measured clinically in echocardiography as mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE), but has not been applied widely in cardiovascular magnetic resonance (CMR). To date, there is no robust automatic algorithm available that allows the AVPD to be measured clinically in CMR with input in a single timeframe. This study aimed to develop, validate and provide a method that automatically tracks the left and right ventricular AVPD in CMR images, which can be used in the clinical setting or in applied cardiovascular research in multi-center studies. METHODS: The proposed algorithm is based on template tracking by normalized cross-correlation combined with a priori information by principal component analysis. The AVPD in each timeframe is calculated for the left and right ventricle separately using CMR long-axis cine images of the 2, 3, and 4-chamber views. The algorithm was developed using a training set (n = 40), and validated in a test set (n = 113) of healthy subjects, athletes, and patients after ST-elevation myocardial infarction from 10 centers. Validation was done using manual measurements in end diastole and end systole as reference standard. Additionally, AVPD, peak emptying velocity, peak filling velocity, and atrial contraction was validated in 20 subjects, where time-resolved manual measurements were used as reference standard. Inter-observer variability was analyzed in 20 subjects. RESULTS: In end systole, the difference between the algorithm and the reference standard in the left ventricle was (mean ± SD) -0.6 ± 1.9 mm (R = 0.79), and -0.8 ± 2.1 mm (R = 0.88) in the right ventricle. Inter-observer variability in end systole was -0.6 ± 0.7 mm (R = 0.95), and -0.5 ± 1.4 mm (R = 0.95) for the left and right ventricle, respectively. Validation of peak emptying velocity, peak filling velocity, and atrial contraction yielded lower accuracy than the displacement measures. CONCLUSIONS: The proposed algorithm show good agreement and low bias with the reference standard, and with an agreement in parity with inter-observer variability. Thus, it can be used as an automatic method of tracking and measuring AVPD in CMR.
Seemann et al. (Mon,) conducted a observational in Healthy subjects, athletes, and patients with ST-elevation myocardial infarction (n=153). Automatic tracking algorithm for AVPD vs. Manual measurements was evaluated on Difference between automatic tracking and manual measurements of AVPD in end systole (left ventricle) (Mean difference -0.6 mm). The automatic tracking algorithm for atrioventricular plane displacement in CMR images showed good agreement with manual measurements, with a mean bias of -0.6 mm in the left ventricle and -0.8 mm in the right ventricle.