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Abstract Background Enterotoxigenic Escherichia coli ( E. coli ) is one of the most prevalent causes of diarrhea in young animals. Postbiotics derived from yeast have the potential to positively influence the mucosal microbiota in the jejunum, therefore it was hypothesized that Saccharomyces yeast postbiotics could enhance the microbiota and mucosal immune response in the jejunum, mitigating the effects of infection with enterotoxigenic E. coli . The purpose of this study was to investigate the effects of a Saccharomyces yeast postbiotic on the mucosal microbiota and mucosal immune response in the jejunum of newly weaned pigs challenged with F18 + E. coli. Results Thirty-six individually housed nursery pigs were allotted into three treatments utilizing a randomized complete block design; negative control (NC: basal diet, no challenge), positive control (PC: basal diet, challenge), and SYP (basal diet + Saccharomyces yeast postbiotics at 175 g/ton , challenge). On d 7, PC and SYP were orally inoculated with F18 + E. coli , whereas NC received saline. On d 28, pigs were euthanized for sampling of the jejunum to analyze the mucosal microbiota, oxidative stress, immune status, and intestinal morphology. The PC reduced ( P < 0.05) growth performance compared to NC. The SYP improved ( P < 0.05) fecal score from d 7–18 when compared with PC. SYP reduced ( P < 0.05) protein carbonyl, reduced ( P < 0.05) gene expression of Toll-like receptor 4, and increased ( P < 0.05) gene expression of mammalian target of rapamycin, compared with PC. Conclusions Challenge with F18 + E. coli negatively impacted jejunal mucosa-associated microbiota and jejunal morphology, affecting growth performance. Saccharomyces yeast postbiotics could reduce the negative effects associated with F18 + E. coli infection.
Gormley et al. (Fri,) studied this question.