Plasma BNP levels > 90 pg/ml were strongly associated with the diagnosis of right ventricular dysfunction in patients with acute pulmonary embolism (RR 165; 95% CI 13.7-1987.2).
Cross-Sectional (n=40)
Does B-type natriuretic peptide (BNP) measurement accurately diagnose right ventricular dysfunction in patients with acute pulmonary embolism?
Plasma BNP levels > 90 pg/ml are strongly associated with right ventricular dysfunction in patients with acute pulmonary embolism.
Relative Risk: 165 (95% CI 13.7–1987.2)
OBJECTIVE: B-type natriuretic peptide (BNP) is a neurohormone secreted from cardiac ventricles in response to ventricular strain. The aim of present study was to evaluate the role of BNP in the diagnosis of the right ventricular (RV) dysfunction in acute pulmonary embolism (PE). METHODS: BNP levels were measured in patients with acute PE as diagnosed by high probability lung scan or positive spiral computed tomography. All patients underwent standard echocardiography and blood tests during the second hour of the diagnosis. RESULTS: Forty patients diagnosed as acute PE (mean age, 60.4 +/- 13.2 years; 62.5% women) were enrolled in this study. Patients with RV dysfunction had significantly higher BNP levels than patients without RV dysfunction (426 +/- 299.42 pg/ml vs. 39.09 +/- 25.22 pg/ml, p 90 pg/ml was associated with a risk ratio of 165 (95% CI, 13.7-1987.2) for the diagnosis of RV dysfunction. There was a significant correlation between RV end-diastolic diameter and BNP (r = 0.89, p 90 pg/ml should be strongly considered.
Yardan et al. (2007) conducted a cross-sectional in acute pulmonary embolism (n=40). B-type natriuretic peptide (BNP) > 90 pg/ml vs. BNP ≤ 90 pg/ml was evaluated on Diagnosis of right ventricular (RV) dysfunction (RR 165, 95% CI 13.7-1987.2). Plasma BNP levels > 90 pg/ml were strongly associated with the diagnosis of right ventricular dysfunction in patients with acute pulmonary embolism (RR 165; 95% CI 13.7-1987.2).