People of African descent had a significantly lower mean percentage nocturnal fall in systolic blood pressure compared with White populations (MD -3.07; 95% CI -3.81 to -2.33; P<0.00001).
Meta-Analysis
Yes
Does nocturnal blood pressure fall differ in people of African and South Asian descent compared to European white populations?
People of African descent have significantly smaller nocturnal blood pressure falls compared to European white populations, which may contribute to higher rates of hypertension complications.
Mean Difference: -3.07 (95% CI -3.81–-2.33)
p-value: p=< 0.00001
OBJECTIVE: To assess whether nocturnal blood pressure fall in people of African (Black) and South Asian descent differs from that of the European origin white populations (White). METHODS: A systematic literature review was carried out using Medline 1966-2003 and Embase 1980-2003, and citations from references. The meta-analysis was performed using Cochrane review manager software (RevMan version 4.2; The Cochrane Collaboration, Oxford, UK). RESULTS: Seventeen studies were identified; 11 studies from the USA, one from the USA and Canada, and six studies from the United Kingdom. The mean percentage systolic blood pressure (SBP) nocturnal fall was below 10% (non-dipping) in 10 of 17 studies (59%) and the diastolic blood pressure (DBP) nocturnal fall was below 10% in four of 16 studies (25%) in Blacks compared with four of 17 studies (24%) in SBP and none in DBP nocturnal falls in Whites. Compared with Whites, Blacks had a significantly lower mean percentage nocturnal fall; the overall weighted mean difference in SBP was -3.07 (95% confidence interval, -3.81, -2.33; P < 0.00001) and in DBP was -2.98 (95% confidence interval, -3.97, -2.00; P < 0.00001). Two studies on South Asians showed a higher SBP but a similar mean DBP nocturnal fall compared with Whites. CONCLUSION: Smaller nocturnal blood pressure falls and a higher prevalence of non-dipping may contribute to the higher levels of hypertension complications seen in Black people. No such phenomenon was seen in South Asians but more research is needed to explore their higher stroke mortality.
Agyemang et al. (Fri,) conducted a meta-analysis in Nocturnal blood pressure fall. African (Black) descent vs. European origin white populations was evaluated on Mean percentage systolic blood pressure (SBP) nocturnal fall (MD -3.07, 95% CI -3.81, -2.33, p=< 0.00001). People of African descent had a significantly lower mean percentage nocturnal fall in systolic blood pressure compared with White populations (MD -3.07; 95% CI -3.81 to -2.33; P<0.00001).
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