Enamine-Based Organocatalysis with Proline and Diamines:  The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels−Alder Reactions

Key Points

• The aim is to develop a catalytic asymmetric strategy utilizing enamines and imines inspired by enzymatic processes.
• Focused on converting enzymatic enamines and imines into a catalytic strategy.
• Employed small organic molecules in the catalytic processes.
• Explored direct aldol, Mannich, Michael, and Diels−Alder reactions.
• Demonstrated successful use of enamines in asymmetric synthesis.
• Provided evidence of efficiency in converting enzymatic strategies to organocatalytic ones.
• Showed potential for diverse applications using the developed methods.