HIV infection was associated with significantly impaired brachial artery flow-mediated dilation compared with uninfected controls (7.3% vs. 11.1%; P < .0001).
Cross-Sectional (n=298)
Does HIV infection impair endothelial vasomotor function compared to uninfected controls?
HIV infection is associated with significantly impaired endothelial function, particularly among injection drug users and those with elevated HIV replication, independent of protease inhibitor therapy.
Absolute Event Rate: 7.3% vs 11.1%
p-value: p=< .0001
BACKGROUND: Several reports have suggested an increased risk of coronary disease in human immunodeficiency virus (HIV)-infected patients receiving protease inhibitors (PIs). Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease. METHODS: The present study evaluated the effect of HIV infection and antiretroviral treatment on endothelial vasomotor function, by assessing brachial artery flow-mediated dilation (FMD). A total of 75 HIV-infected patients were compared with 223 control subjects who were presumed to be HIV uninfected. RESULTS: HIV-infected patients had significantly impaired FMD, compared with control subjects (mean +/- SD, 7.3% +/- 4.4% vs. 11.1% +/- 6.3%; P < .0001). When adjustments were made for smoking status, sex, and body mass index, the difference between the 2 groups remained statistically significant (P < .01). In a cross-sectional analysis of the HIV-infected patients, we found significant associations between FMD and current injection drug use, hazardous drinking, HIV load, and alpha-high-density lipoprotein triglyceride levels, but not PI therapy. In a multivariate analysis, only current injection drug use and a lower alpha-high-density lipoprotein triglyceride level were significantly associated with FMD. CONCLUSIONS: HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users.
Solages et al. (Thu,) conducted a cross-sectional in HIV infection (n=298). HIV infection vs. Presumed HIV-uninfected control subjects was evaluated on brachial artery flow-mediated dilation (FMD) (p=< .0001). HIV infection was associated with significantly impaired brachial artery flow-mediated dilation compared with uninfected controls (7.3% vs. 11.1%; P < .0001).
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