Age-associated changes in voltage-gated sodium channel isoforms may predispose the elderly heart to atrial fibrillation.
Do age-associated changes of voltage-gated sodium channel isoforms predispose the elderly to atrial fibrillation?
Age-associated changes in voltage-gated sodium channels may play a crucial role in predisposing the elderly to atrial fibrillation, presenting a potential therapeutic target.
8 in both heart failure and ventricular hypertrophy. This strongly suggests that the expression of voltage-gated sodium channels play a crucial role in the development of arrhythmias in the diseased heart. Targeting aberrant sodium currents has led to novel therapeutic approaches in tackling AF and continues to be an area of emerging research. This review will explore how voltage-gated sodium channels may predispose the elderly heart to AF through the examination of laboratory and clinical based evidence.
Isaac et al. (Wed,) conducted a review in Atrial fibrillation. Age-associated changes of voltage-gated sodium channel isoforms was evaluated. Age-associated changes in voltage-gated sodium channel isoforms may predispose the elderly heart to atrial fibrillation.