Asymptomatic patients with type 1 diabetes had higher mean carotid intima-media thickness than controls (0.55 vs 0.48 mm, P<0.01), though 82% had a coronary calcium score of 0.
Cross-Sectional (n=200)
Does type 1 diabetes increase the prevalence of subclinical atherosclerosis compared to nondiabetic controls in asymptomatic patients?
Asymptomatic patients with type 1 diabetes have a low prevalence of subclinical coronary atherosclerosis, suggesting that universal screening with CACS is not justified in this population.
Absolute Event Rate: 0.55% vs 0.48%
p-value: p=<0.01
OBJECTIVE: To evaluate the presence of early carotid and coronary atherosclerosis in asymptomatic patients with type 1 diabetes with no history of ischemic heart disease. RESEARCH DESIGN AND METHODS: One hundred and fifty patients with type 1 diabetes (58% males; 38.6 ± 8.1 years, 20.4 ± 8.1 years of evolution; HbA1c 8.1 ± 2.3%; 52% nonsmokers; 26% retinopathy; 9% microalbuminuria) and 50 nondiabetic control subjects age and sex matched were studied. Carotid ultrasonography to determine common carotid artery intima-media thickness (c-IMT) and the presence of atheroma plaques and cardiac computed tomography for calcium analysis and quantification (coronary artery calcium score CACS) were performed. RESULTS: Most patients with type 1 diabetes and control subjects displayed a CACS of 0 (82 vs. 92%). Patients with type 1 diabetes with CACS ≥1 were older and had higher HbA1c (44.5 ± 5.1 vs. 36.7 ± 8.1 years P < 0.001 and 8.5 ± 1.1 vs. 7.8 ± 1.0% P < 0.003, respectively) and longer evolution of diabetes (25.4 ± 9.2 vs. 19.3 ± 7.4 years, P < 0.005) and mean c-IMT (0.67 ± 0.18 vs. 0.53 ± 0.11 mm, P < 0.001) compared with patients with CACS of 0. Smoking (P < 0.02), nephropathy (P < 0.05), retinopathy (P < 0.05), and male sex (P < 0.03) were significantly and positively associated with CACS ≥1. Mean c-IMT was significantly higher in patients with type 1 diabetes (0.55 ± 0.14 vs. 0.48 ± 0.14 mm, P < 0.01), and 11% of them presented atheroma plaques (8% of control subjects). Multivariant logistic regression analysis showed that c-IMT was related to CACS (β = 6.87, P < 0.001). CONCLUSIONS: A small percentage of patients with type 1 diabetes showed data suggestive of subclinical atherosclerosis. Universal screening of coronary disease in this population is not justified. Carotid ultrasonography may be useful for screening in the subset of patients with cardiovascular risk factors and long disease evolution.
Aguilera et al. (Fri,) conducted a cross-sectional in Type 1 diabetes (n=200). Type 1 diabetes vs. Nondiabetic control subjects was evaluated on Mean common carotid artery intima-media thickness (c-IMT) in mm (p=<0.01). Asymptomatic patients with type 1 diabetes had higher mean carotid intima-media thickness than controls (0.55 vs 0.48 mm, P<0.01), though 82% had a coronary calcium score of 0.
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