Early high-intensity statin therapy was associated with a lower incidence of early neurological deterioration compared to moderate-intensity statin therapy (aOR 0.44; 95% CI 0.25-0.77; p=0.004).
Cohort (n=492)
Does early high-intensity statin therapy reduce the incidence of early neurological deterioration in patients with single small subcortical infarction compared to moderate-intensity statin therapy?
Early administration of high-intensity statin therapy within 24 hours of symptom onset is associated with a significantly reduced incidence of early neurological deterioration in patients with single small subcortical infarction.
Odds Ratio: 0.44 (95% CI 0.25–0.77)
p-value: p=0.004
Backgrounds: One of the major hypotheses for early neurological deterioration (END) in single small subcortical infarction (SSSI) is the process of atherosclerosis. However, the association between statin therapy, especially high-intensity statin therapy, and its effectiveness in reducing the incidence of END during the acute phase of SSSI remains unclear. This study aimed to investigate the influence of high-intensity statin therapy compared to moderate-intensity statin therapy during the acute phase on the incidence of END in SSSI. Methods: The records of 492 patients with SSSI who received statin therapy within 72 h of symptom onset from a prospective stroke registry were analyzed. The association between END and statin intensity was evaluated using multivariable regression analysis for adjusted odds ratio (aOR). Results: Of the 492 patients with SSSI (mean age: 67.2 years, median NIHSS score on admission: 3), END occurred in 102 (20.7%). Older age (aOR, 1.02; 95% confidence interval (CI), 1.00–1.05; p = 0.017), and branch atheromatous lesion (aOR, 3.49; 95% CI 2.16–5.74; p < 0.001) were associated with END. Early high-intensity statin therapy was associated with a lower incidence of END than moderate-intensity statin therapy (aOR, 0.44; 95% CI, 0.25–0.77; p = 0.004). In addition, there was significantly lower incidence of END in early administration (≤24 h) of high-intensity statin group. Conclusions: We identified an association between the intensity of early statin therapy and END in patients with SSSI. Early administration of high-intensity statin (≤24 h) is associated with a reduced incidence of END in patients with SSSI.
Jang et al. (Wed,) conducted a cohort in Single small subcortical infarction (SSSI) (n=492). High-intensity statin therapy vs. Moderate-intensity statin therapy was evaluated on Early neurological deterioration (END) (aOR 0.44, 95% CI 0.25-0.77, p=0.004). Early high-intensity statin therapy was associated with a lower incidence of early neurological deterioration compared to moderate-intensity statin therapy (aOR 0.44; 95% CI 0.25-0.77; p=0.004).