Thiazide diuretics are safe, effective, and well tolerated as monotherapy or in combination for the management of hypertension, despite concerns about metabolic changes.
BACKGROUND: The use of thiazide diuretics has decreased over the past 30 years despite data from many well-controlled clinical trials demonstrating that the use of these agents as monotherapy or in combination with other antihypertensive agents will reduce blood pressure and decrease cardiovascular as well as cerebrovascular events. METHODS: We reviewed clinical and experimental data on thiazide diuretics since their introduction in the late 1950s. RESULTS: The results of thiazide-based therapy in young and old are consistently positive despite concerns about some metabolic changes, eg, insulin resistance or hypokalemia, that may occur. CONCLUSION: We conclude that these agents are safe, effective, and well tolerated and should continue to be used either as monotherapy or with other medications in the management of hypertension.
Marvin Moser (Mon,) conducted a review in Hypertension. Thiazide diuretics was evaluated. Thiazide diuretics are safe, effective, and well tolerated as monotherapy or in combination for the management of hypertension, despite concerns about metabolic changes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: