September 1, 1995
View Full PaperNoninvasive Pulse Wave Analysis for the Early Detection of Vascular Disease
Structured PICO
Can noninvasive pulse wave analysis detect changes in systemic arterial compliance in vascular disease states and in response to vasodilator drugs?
P
Population
Subjects with hypertension, postmenopausal women with symptomatic coronary artery disease, and appropriate control subjects
I
Intervention
Noninvasive pulse wave analysis using a modified Windkessel model
C
Comparator
Appropriate control subjects
O
Outcome
Capacitive and oscillatory systemic arterial compliancesurrogate
Noninvasive pulse wave analysis using a modified Windkessel model can detect reduced oscillatory compliance in vascular disease and monitor compliance increases following vasodilator therapy.
Abstract
A noninvasive technique has been developed and validated for calculating capacitive and oscillatory systemic arterial compliance with the use of pulse wave analysis and a modified Windkessel model. Application of the technique to subjects with hypertension, postmenopausal women with symptomatic coronary artery disease, and appropriate control subjects has confirmed a reduction of oscillatory compliance in the disease states and an increase in capacitive and oscillatory compliances in response to vasodilator drugs. This method should be useful in screening subjects for early evidence of vascular disease and in monitoring the response to therapy.