In adults with Marfan syndrome, emergent initial operation (OR 3.38; 95% CI 1.97-5.80) and hypertension (OR 2.39; 95% CI 1.54-3.72) were independently associated with increased odds of redo sternotomy.
Cohort (n=783)
Yes
What are the predictors of redo sternotomy in adults with Marfan syndrome undergoing cardiac surgery?
In adults with Marfan syndrome, cardiac surgery is common and redo sternotomy is frequently required, with hypertension, emergent initial operation, and postoperative complications being significant predictors.
Odds Ratio: 3.38 (95% CI 1.97–5.8)
Background Marfan syndrome (MFS) is associated with progressive aortic and valvular disease requiring cardiac surgery, but contemporary data on repeat cardiac operations in adults remain limited. Methods We performed a retrospective multicentre cohort study of 783 adults with MFS evaluated across three Mayo Clinic sites. Cardiac operations, postoperative complications, echocardiographic findings and redo sternotomy events were identified by chart review. Multivariate logistic regression was used to evaluate factors associated with redo sternotomy. Results Overall, 454 patients (58.0%) underwent at least one cardiac operation, and 185 patients (23.6% of the total cohort; 41.0% of operated patients) required redo sternotomy. The most common procedures were aortic root intervention (53.4%), aortic valve intervention (39.6%), mitral valve intervention (16.1%) and tricuspid valve intervention (2.6%). Valvular abnormalities were frequent, including mitral regurgitation (51.5%), mitral valve prolapse (41.1%), tricuspid regurgitation (44.6%) and aortic regurgitation (28.5%). Major postoperative complications occurred in 15.3% of patients. On multivariate analysis, hypertension (OR 2.39, 95% CI 1.54 to 3.72), emergent initial operation (OR 3.38, 95% CI 1.97 to 5.80) and postoperative complications (OR 2.59, 95% CI 1.58 to 4.27) were independently associated with redo sternotomy, whereas repair extending beyond the aortic root was associated with lower odds (OR 0.39, 95% CI 0.29 to 0.53). Conclusion In this large multicentre cohort of adults with MFS, cardiac surgery was common, and redo sternotomy occurred frequently among operated patients. These findings provide a contemporary description of the long-term need for cardiac surgery in adults with MFS managed at tertiary referral centres.
Nabi et al. (Thu,) conducted a cohort in Marfan syndrome (n=783). Emergent initial operation vs. Non-emergent initial operation was evaluated on redo sternotomy (OR 3.38, 95% CI 1.97-5.80). In adults with Marfan syndrome, emergent initial operation (OR 3.38; 95% CI 1.97-5.80) and hypertension (OR 2.39; 95% CI 1.54-3.72) were independently associated with increased odds of redo sternotomy.