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Content validity of the Familial Chylomicronemia Syndrome Symptoms and Impacts Scale (FCS-SIS) for severe hypertriglyceridemia (sHTG) | Synapse
June 4, 2026
Open Access
Content validity of the Familial Chylomicronemia Syndrome Symptoms and Impacts Scale (FCS-SIS) for severe hypertriglyceridemia (sHTG)
AK
Asia Sikora Kessler
Ionis Pharmaceuticals (United States)
TB
TM Brown
Patient-Centered Outcomes Research Institute
BB
Bonita Basnyat
Patient-Centered Outcomes Research Institute
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Key Points
To assess the content validity of the Familial Chylomicronemia Syndrome Symptoms and Impacts Scale for patients with severe hypertriglyceridemia.
Conducted a validation study involving patient interviews to gather insights on symptoms and impacts.
Used qualitative analysis to ensure the scale accurately reflects patient experiences related to severe hypertriglyceridemia.
Identified major symptoms and impacts relevant to patients, enhancing the scale's content validity.
Validated FCS-SIS as a reliable tool for measuring the effects of severe hypertriglyceridemia on daily life.
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Cite This Study
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Kessler et al. (Wed,) studied this question.
synapsesocial.com/papers/6a211d5cd499ed480b170fe1
https://doi.org/https://doi.org/10.1080/1179271x.2026.2672471