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Sialic acid has been demonstrated in the blood platelets of man and other species (1, 2), but its function in these elements is unknown. Jeru- shalmy, Kohn, and de Vries (3) and others (4, 5) have shown that Myxoviruses are adsorbed to and eluted from blood platelets. Bacterial neur- aminidase, which liberates free sialic acid by cleavage of the a-ketosidic linkage between ter- minal sialic acid and galactose or galactosamine (6), interferes with these platelet adsorptionelution phenomena (3) in a manner qualitatively similar to its effect on erythrocytes (7) and leu- kocytes (8). The electrophoretic mobility of platelets is reduced after neuraminidase treatment (3), again mimicking the behavior of the other blood elements (9, 10).
Madoff et al. (Fri,) studied this question.
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