Elevated serum lipoprotein(a) levels independently predicted severe aortic stenosis but were not associated with increased risk of aortic valve replacement and cardiac death (P=0.239).
Cohort (n=652)
Does elevated serum lipoprotein(a) predict severe aortic stenosis and increase the risk of aortic valve replacement or cardiac death in Chinese patients with calcific aortic valve stenosis?
In Chinese patients with calcific aortic valve stenosis, elevated Lp(a) predicts echocardiographic severity but does not significantly increase the risk of hard clinical outcomes like AVR or cardiac death.
p-value: p=0.239
BACKGROUND: There was a causal relationship between elevated lipoprotein(a) Lp(a) levels and increased risk of calcific aortic valve stenosis (CAVS) in whites and blacks. The present study aimed to investigate whether Lp(a) levels were associated with aortic stenosis (AS) severity and clinical events in Chinese patients. METHODS: Levels of serum Lp(a) were measured in 652 patients with CAVS, whom all underwent baseline echocardiographic examination. The clinical endpoint was defined as a composite of aortic valve replacement (AVR) and cardiac death. RESULTS: = 0.239) in the multivariate Cox regression analysis during a mean follow-up time of 3.16 ± 2.74 years. CONCLUSIONS: Elevated Lp(a) level was an independent predictor of severe AS by echocardiography in the Chinese population, but was not associated with the increased risk of AVR and cardiac death, suggesting that Lp(a) levels might be helpful in the risk stratification of patients with CAVS.
Liu et al. (Sun,) conducted a cohort in Calcific aortic valve stenosis (CAVS) (n=652). Elevated serum lipoprotein(a) levels was evaluated on Composite of aortic valve replacement (AVR) and cardiac death (p=0.239). Elevated serum lipoprotein(a) levels independently predicted severe aortic stenosis but were not associated with increased risk of aortic valve replacement and cardiac death (P=0.239).