Intravenous immune globulin (750 mg/kg) did not reduce viremia or viruria overall, but IVIG with high neutralization titers (≥1:800) led to more rapid cessation of viremia and viruria.
RCT (n=16)
Randomized
Does intravenous immune globulin improve serum neutralization titers and reduce viremia and viruria in neonates with enterovirus infection?
Standard IVIG administration in neonatal enterovirus infection does not reduce viremia or viruria, highlighting the potential need for high-titer specific IVIG preparations.
A prospective study of the virology of and serological responses to enterovirus infection in 16 neonates ( or = 1:800 to the patients' own viral isolates was associated with significantly higher serum neutralization titers and more rapid cessation of viremia and viruria. Future trials of IVIG for neonatal enterovirus disease should assess the efficacy and safety of higher or repeated doses of this agent and/or of IVIG selected for their high titers to frequently circulating and/or particularly virulent enterovirus serotypes.
Abzug et al. (Mon,) conducted a rct in Neonatal enterovirus infection (n=16). Intravenous immune globulin (IVIG) vs. Controls was evaluated on Serum neutralization titers and daily incidence of viremia and viruria. Intravenous immune globulin (750 mg/kg) did not reduce viremia or viruria overall, but IVIG with high neutralization titers (≥1:800) led to more rapid cessation of viremia and viruria.
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