Idiopathic ventricular tachycardia originating from the right ventricular outflow tract accounts for up to 80% of cases and is likely related to cAMP-mediated triggered activity.
This review summarizes the clinical characteristics and experimental evidence of adenosine-sensitive, right ventricular outflow tract idiopathic VT.
Idiopathic ventricular tachycardia (VT) is a term that refers to tachycardia that arises from ventricles devoid of apparent structural abnormalities. This form of VT is now recognized to be related to several distinct entities and includes a reentrant form typically located in the region of the left posterior fascicle, an automatic form that may originate from either ventricle, and a form that originates from the right ventricular outflow tract. This last type can account for up to 80% of cases of idiopathic VT and with few exceptions can be further subdivided into repetitive monomorphic VT and paroxysmal stress-induced VT. Evidence has accumulated suggesting that both forms of VT are related to cAMP-mediated triggered activity. The experimental underpinnings of this conclusion as well as the clinical characteristics of this form of idiopathic VT are elucidated in this review.
Lerman et al. (Sat,) conducted a review in Idiopathic ventricular tachycardia. Idiopathic ventricular tachycardia originating from the right ventricular outflow tract accounts for up to 80% of cases and is likely related to cAMP-mediated triggered activity.