Hypertrophic cardiomyopathy patients with conduction disturbances or decreased negative T waves showed a higher MIBG clearance rate (0.25 vs 0.10; p<0.05) than those with increased negative T waves.
Observational (n=22)
No
Does regional myocardial sympathetic nerve activity correlate with electrocardiographic and cardiac functional changes in patients with hypertrophic cardiomyopathy?
Abnormalities in regional myocardial sympathetic nerve activity, assessed by MIBG scintigraphy, correlate with electrocardiographic progression and suspected myocardial damage in hypertrophic cardiomyopathy.
Absolute Event Rate: 0.25% vs 0.1%
p-value: p=<0.05
OBJECTIVE: To investigate the relation between regional myocardial sympathetic nerve activity and the electrocardiographic and cardiac functional changes in hypertrophic cardiomyopathy. DESIGN: A retrospective study to compare the findings of myocardial scintigraphy with iodine-123 metaiodobenzylguanidine (MIBG) and the serial electrocardiographic changes. SETTING: Myocardial scintigraphy was performed with iodine-123 MIBG and thallium-201 and single photon emission computed tomography (SPECT) in the division of nuclear medicine of Kanazawa University Hospital. Both SPECT studies were performed within a week. PATIENTS: 22 patients with hypertrophic cardiomyopathy classified according to their serial electrocardiographic changes--namely, 15 patients with an increase in or the appearance of a negative T wave (group A) and seven patients with a conduction disturbance or a decrease in or disappearance of the negative T wave (group B). The mean follow up period was 45 (range 12-143) months. RESULTS: Group B showed a high rate of decreased activity or defects in MIBG uptake compared with group A (p less than 0.005). The areas of decreased activity or defects corresponded with the hypertrophied portion of the left ventricular wall. Although the early myocardial uptake (MIBG: thallium ratio) was similar in both groups, the mean (SD) MIBG clearance rate was significantly higher (p less than 0.05) in group B (0.25 (0.17)) than in group A (0.10 (0.15)). CONCLUSION: Abnormalities of regional myocardial sympathetic nerve activity may be important in patients with hypertrophic cardiomyopathy and suspected progression of myocardial damage.
Shimizu et al. (Sat,) conducted a observational in Hypertrophic cardiomyopathy (n=22). Conduction disturbance or decreased/disappeared negative T wave (Group B) vs. Increased or new negative T wave (Group A) was evaluated on MIBG clearance rate (p=<0.05). Hypertrophic cardiomyopathy patients with conduction disturbances or decreased negative T waves showed a higher MIBG clearance rate (0.25 vs 0.10; p<0.05) than those with increased negative T waves.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: