Low skeletal muscle mass independently predicted higher 3-year all-cause mortality compared to high muscle mass in CAD patients undergoing PCI (HR 4.07; 95% CI 1.95-8.45; p<0.001).
Cohort (n=475)
No
Does low skeletal muscle mass predict all-cause mortality and MACEs in patients with CAD undergoing PCI?
CT-diagnosed low skeletal muscle mass (sarcopenia) is a powerful independent predictor of 3-year all-cause mortality and MACEs in patients with CAD undergoing PCI.
Hazard Ratio: 4.07 (95% CI 1.95–8.45)
Absolute Event Rate: 23.7% vs 5.9%
p-value: p=< 0.001
The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm2/m2, female <25.00 cm2/m2) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%, p < 0.001) and MACEs (39.6% vs. 11.8%, p < 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95–8.45; p < 0.001) and MACEs (HR: 3.76; 95% CI: 2.27–6.23; p < 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.
Kang et al. (Sun,) conducted a cohort in Coronary artery disease (CAD) (n=475). Low skeletal muscle mass vs. High skeletal muscle mass was evaluated on 3-year all-cause mortality (HR 4.07, 95% CI 1.95-8.45, p=< 0.001). Low skeletal muscle mass independently predicted higher 3-year all-cause mortality compared to high muscle mass in CAD patients undergoing PCI (HR 4.07; 95% CI 1.95-8.45; p<0.001).