Occurrence of Pick's Disease in Early Adult Years

Since Pick's original description in 1892, there have been numerous publications dealing with the pathoanatomic picture of Pick's disease. These reports have described the distribution of the atrophy and the histologic changes and have presented sufficient evidence to establish the disease as a pathoanatomic entity. There remains the task of carefully outlining the clinical picture, defining the differential diagnostic features and discovering the hereditary and other pathogenetic factors. Although it was originally believed that the disease occurs only at an advanced age, there have been recent contributions showing that the syndrome may begin as early as the third decade. We wish to report a case of Pick's disease in which there were definite hereditary features and the disease began in early adult years. REPORT OF A CASEClinical History. —C. W., a well developed white man aged 25, was admitted on Oct. 31, 1935, because of advanced mental deterioration. The