A mathematical model incorporating a force-dependent rate constant accurately reproduced dynamic isometric force generation in cat skeletal muscles across various stimulation patterns.
A mathematical model incorporating a force-dependent rate constant accurately predicts dynamic isometric force generation in skeletal muscle, offering potential applications in neuroprosthesis control.
The force that an isometric skeletal muscle will produce in response to time-varying stimulation ("dynamic isometric" force) is important both for understanding muscle function and for designing neuroprostheses. This paper reports a model for predicting the force produced by an isometric skeletal muscle at rest length in response to a wide range of stimulation patterns. The model consists of two linear, first-order systems separated by a static nonlinearity. The rate constant of the second first-order system varies with force level. The model was validated using three cat soleus and three cat plantaris muscles. The following whole-nerve stimulation trains were used: single pulses (twitches), 2-4 pulses, constant rates, triangularly modulated interpulse intervals, and randomly modulated interpulse intervals. The model reproduced most responses accurately. The model shows that a force-dependent rate constant is essential for model validity, and could be used in the control of neuroprostheses.
Bobet et al. (Thu,) conducted a other in Skeletal muscle force generation (n=6). Mathematical model with force-dependent rate constant was evaluated on Model accuracy in predicting force produced by isometric skeletal muscle in response to stimulation patterns. A mathematical model incorporating a force-dependent rate constant accurately reproduced dynamic isometric force generation in cat skeletal muscles across various stimulation patterns.
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