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Invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease through coordinated tissue infiltration and residence. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 13, 2021Open Access

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease

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Abstract

Flow cytometric and transcriptomic analyses reveal coordinated tissue infiltration and tissue residence of donor T cells that drive gastrointestinal GVHD.

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Tkachev et al. (Wed,) studied this question.

synapsesocial.com/papers/6a23e70f1c36a2d27b9ef1a9 https://doi.org/https://doi.org/10.1126/scitranslmed.abc0227

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets2005 · 353 citations
2Selective depletion of CD8+ T lymphocytes for prevention of graft- versus-host disease after allogeneic bone marrow transplantation1990 · 179 citations
3Lineage tracking reveals dynamic relationships of T cells in colorectal cancer2018 · 1,549 citations
4Phenotypic Analysis Of Donor Cells Infiltrating The Small Intestinal Epithelium And Spleen During Graft-Versus-Host Disease1995 · 19 citations
5Selective depletion of CD8+ T lymphocytes for prevention of graft- versus-host disease after allogeneic bone marrow transplantation1990 · 167 citations

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