What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Primary hypertension (n=60). Intervention: Medication adherence. Primary outcome: Correlation between adherence and clinical outcomes (blood pressure) (r= -0.745, p=<0.05).

December 31, 2020Open Access

Effect of Adherence with Clinical Outcomes and Quality of Life Primary Hypertension Patients in Pharmacy

Q: What are the key findings of this study?

Medication adherence in primary hypertension patients was significantly correlated with clinical outcomes (r=-0.745, p<0.05) and quality of life (r=0.554, p<0.05).

DHDumartina HutaurukUniversitas Sari Mutiara Indonesia KKKhairunnisa KhairunnisaTelkom University WWWiryanto WiryantoUniversitas Sumatera Utara

Key Result

Medication adherence in primary hypertension patients was significantly correlated with clinical outcomes (r=-0.745, p<0.05) and quality of life (r=0.554, p<0.05).

Study Design

Type

Cross-Sectional (n=60)

Multicenter

Structured PICO

Does medication adherence correlate with blood pressure and quality of life in primary hypertension patients?

Population

60 primary hypertension patients (60% female) evaluated at a single pharmacy in Medan, Indonesia.

Exposure

Medication adherence (assessed via MMAS-8 questionnaire)

Outcome

Clinical outcomes (blood pressure) and quality of life (assessed via EQ-5D-3L questionnaire)surrogate

Medication adherence is strongly correlated with improved blood pressure control and moderately correlated with better quality of life in primary hypertension patients.

Main Result

Effect estimate: r= -0.745

p-value: p=<0.05

Abstract

This study aimed to examine the effect of adherence to clinical outcomes and the quality of life of primary hypertension patients in pharmacy. The studywas conducted cross sectionally involved 60 patients at one of the pharmacies in Medan, Indonesia. Adherence was obtained in the form of adherence levels measured using the MMAS-8 questionnaire, clinical outcomes assessed by measuring a patient's blood pressure, and quality of life assessed using the EQ-5D-3L questionnaire. Then the data were analyzed using the Spearmen rho test. Patients who participated in the study consisted of 24 men and 36 women. Almost patient has low adherence with blood pressure mean of 156/ 90 mmHg. The patient's quality of life was 77.7%. Adherence has a significant relationship to clinical outcomes (p<0.05) with a strong correlation of r= -0.745. Adherence has a relationship to quality of life (p<0.05) with moderate correlation r= 0.554. This study concluded that adherence has a correlation with clinical outcomes and the quality of life of primary hypertension patients.

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