Abstract Benzimidazoles represent a privileged heterocyclic scaffold of significant importance in medicinal chemistry due to their broad spectrum of biological activities. This review highlights the therapeutic applications of benzimidazole and its derivatives, focusing on their roles as potential agents in the treatment of diverse diseases. Particular emphasis is placed on active benzimidazole scaffolds exhibiting antibacterial, anticancer, antidiabetic, anticoagulant, antipsychotic, antiviral, antioxidant, anti-inflammatory, and antihypertensive properties, among others. The structural versatility of benzimidazoles, coupled with their ability to interact with multiple biological targets, establishes them as a valuable framework for rational drug design and development. By summarizing the advancements in the pharmacological profile of benzimidazole-based compounds, this review aims to provide a comprehensive understanding of their therapeutic potential and to encourage further exploration of this heterocyclic nucleus for future clinical applications.
Sharma et al. (Wed,) studied this question.
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