Background: Outpatient parenteral antimicrobial therapy (OPAT) is increasingly used for complex infections, but data from settings with high prevalence of multidrug-resistant organisms (MDROs) are limited. Methods: We conducted a retrospective observational study of patients treated with OPAT in two tertiary-care hospitals in Southern Italy between 2024 and 2025. Results: Among 119 patients, 51.2% had MDRO infections. Clinical recovery was achieved in 98/109 (89.9%) patients, with low rates of relapse (11/109, 10.1%), hospital readmission (19/109, 17.4%), and adverse events. Recovery, relapse, adverse events, and hospital readmission rates appeared similar between MDRO and non-MDRO groups, and no statistically significant differences were found. Conclusions: These findings suggest that OPAT may be safely and effectively delivered in high-MDRO-prevalence settings when provided within structured, specialist-led hospitals, but it should be interpreted with caution due to the limited sample size and reduced statistical power. The study primarily contributes a detailed characterization of feasibility and stewardship challenges rather than a definitive efficacy comparison, which requires future prospective studies.
Ciusa et al. (Wed,) studied this question.